National Taiwan University Hospital moved to Changde Street in 1898. It was a wooden building at the time, but was later damaged by termites, so reconstruction began in 1912 and was transformed into a Renaissance-style reinforced red brick building, which was completed in 1921. 

In terms of architectural design, a central corridor runs through the entire building, with outpatient clinics and wards arranged in sequence. There are patios and green spaces between the buildings to provide natural lighting and good ventilation. 

In terms of appearance, there are Doric columns at the entrance, which are simple and elegant, while the lobby adopts Ionic design, with grape patterns on the top of the columns and semi-circular windows. The roof design is also very exquisite, including towers, parapets and bull's-eye windows, which make the building more beautiful. 

In the early days, the floor was covered with cypress wood and cowhide, and medical staff had to wear slippers to avoid scratching the floor. There is also a footbath next to the entrance, and traces of the old handrails and faucets can still be seen.